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How should I take Promethazine with Codeine Oral Solution? Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. cost alfuzosin manufacturer alfuzosin

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These side effects include dry mouth, constipation, trouble emptying your bladder, blurred vision, and drowsiness. Neuroleptic Malignant Syndrome NMS has been reported in association with promethazine hydrochloride alone or in combination with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias. NOT be used to treat hypotension associated with promethazine overdose.

Drink plenty of fluids

Appropriate studies have not been performed on the relationship of age to the effects of promethazine in the pediatric population. Safety and efficacy have not been established in children below 2 years of age. Elk Grove Village, IL: American Academy of Pediatrics. Gusdon JP Jr, Herbst GA, Marriot R. The inhibition of polymorphonuclear and lymphocyte-mediated fetal red blood cell lysis by promethazine in vitro. Am J Obstet Gynecol. Promethazine tablets, IM injections and the compounded gel for almost 15 yrs. I am constantly nauseated, suffer from anxiety, and motion sickness, however, this drug does the trick!

Widely distributed in body tissues

Do not use this product to make a child sleepy. It is not known whether promethazine HCl is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Reviews for promethazine

The dosage is based on your age, medical condition, and response to treatment. Phenergan promethazine is used to treat allergy symptoms and prevent motion sickness. Includes Phenergan side effects, interactions and indications. This product can affect the results of certain lab tests such as urine pregnancy tests, skin allergy tests. Make sure laboratory personnel and all your doctors know you use this drug. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS. Since cough and cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Food and Drug Administration. FDA alert for healthcare professionals. Promethazine hydrochloride marketed as Phenergan and generic products. Rockville, MD; April 2006. From FDA Website. The Food and Drug Administration FDA first approved promethazine hydrochloride in 1951. Though very unlikely, abnormal drug-seeking behavior is possible with this medication. Do not increase your dose, take it more frequently, or take it for a longer time than prescribed. Properly stop the medication when so directed. Produces either CNS stimulation or CNS depression sedation; CNS depression is more common with therapeutic doses. Phenadoz, Promethegan a drug used to prevent motion sickness, nausea or vomiting. CYP2D6 or high morphine concentrations. These children may be particularly sensitive to the respiratory depressant effects of codeine that has been rapidly metabolized to morphine. This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Important information

There may be other drugs not listed that can affect dextromethorphan and promethazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain is contraindicated for use in patients less than two years of age. Use a medication-measuring device to carefully measure the prescribed dose. not use a household spoon. You will be asked to tilt your head back and open your as wide as possible. Your doctor will press your down with a flat stick tongue depressor and then examine your and throat. The antihistamine works by blocking the action of histamine to reduce the symptoms of an allergic reaction, such as runny nose and sinus drainage. The cough suppressant works in the brain to decrease the cough reflex. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Use with caution in children with a history of sleep apnea, those with a family history of SIDS, and those who are less prone than usual to spontaneous arousal from sleep. See Cardiovascular Effects under Cautions. Call your doctor if your symptoms do not improve, or if they get worse while using promethazine. Please refer to the for information on shortages of one or more of these preparations. Do not stop taking any medications without consulting your healthcare provider. Breathing problems respiratory depression which can lead to death. Call your healthcare provider or get emergency treatment right away if you have excessive sleepiness, shallow or slow breathing, or confusion. Emotional Polarity Technique Training. Emotional Polarity Technique is the practical, efficient, time saving technique that you have been waiting for. The dose may be repeated eight to twelve hours later if needed. meclizine

Side effects of promethazine

Antihistamines and codeine are both contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma. Take this medication by with or without food, usually every 4 to 6 hours as needed with a full glass of water 8 ounces or 240 milliliters or as directed by your doctor. This medication can be taken with food if upset occurs. Drink plenty of fluids when you use this medication unless otherwise directed by your doctor. This product is usually not used for ongoing cough from smoking or long-term breathing problems such as chronic bronchitis, emphysema unless directed by your doctor. April 29, 2016. Phenergan And Zyrtec Interactions Pentazine - microgen. Do not share it with other people. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using rectal promethazine. Promethazine is also used to prevent and control motion sickness, nausea, vomiting, and dizziness. For people with seizures: This drug raises your risk of seizures. Talk to your doctor if you take other drugs that can cause seizures. Taking these drugs together can increase this risk. This drug comes with several warnings. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. No published studies have indicated whether ramelteon, in humans, is more or less safe or effective than the hormone which it mimics; melatonin is much less expensive and is widely available over-the-counter in the US and Canada. This drug can cause a severe allergic reaction. Dermatologic: Dermatitis, photosensitivity, urticaria.

Common side effects of promethazine

Mann NP. Trimeprazine and respiratory depression. Arch Dis Child. Blurred vision; constipation; dizziness; drowsiness; dry mouth, throat, or nose; headache; nausea; tiredness or weakness; vomiting. Food and Drug Administration. Sulfiting agents; labeling in drugs for human use; warning statement. The management of NMS should include 1 immediate discontinuation of promethazine HCl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. Store in the refrigerator. not freeze. Keep all away from children and pets. Wyeth's Phenergan via IV push. Science, Seaweed and a vision of a better future of farming. Moya F, Thorndike V. Passage of drugs across the placenta. Am J Obstet Gynecol. Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. fluconazole buy uk

Promethazine uses

For information on systemic interactions resulting from concomitant use, see Interactions. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. If any of these effects persist or worsen, tell your doctor or promptly. No matter what form you are using, it's very important that you take it exactly as directed. Overdose symptoms may include overactive reflexes, loss of coordination, severe drowsiness or weakness, fainting, dilated pupils, weak or shallow breathing, or seizure convulsions. What should I avoid while using rectal Promethegan promethazine rectal? Some promethazine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Possible nerve damage ranging from temporary sensory loss to palsies and paralysis. 117 139 Injection near or into a nerve may result in permanent tissue damage. Monoamine Oxidase Inhibitors MAOI: Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Many people have their wisdom removed between the ages of 17 and 25. Often, they go to a special dentist called an oral surgeon, who removes the teeth in his office. Your doctor will ask you about your child's and will schedule any shots that are needed. Children with cystic fibrosis should have all the recommended shots, plus pneumococcal shots. Avoid spending a long time in sunlight. Inform patients and caregivers that potentially fatal additive effects may occur if Promethazine with Codeine Oral Solution is used with benzodiazepines or other CNS depressants, including alcohol. Because of this risk, patients should avoid concomitant use of Promethazine with Codeine Oral Solution with benzodiazepines or other CNS depressants, including alcohol.

General information about promethazine

Hi, I'm Ben I make games. If is likely, a test called a or quick strep may be done before a throat culture. With a rapid strep test, results are ready in 10 minutes instead of 1 to 2 days with a throat culture. If the rapid strep test results are positive, can be started immediately. A throat culture is more accurate than the rapid strep test. The rapid strep test can give even when strep bacteria are present. When the results of a rapid strep test are negative, many doctors recommend doing a throat culture to make sure that strep throat is not present. Promethazine may lead to potentially fatal respiratory depression. Stanton AN. Sudden infant death syndrome and phenothiazines. Pediatrics. If you take certain antidepressant drugs called monoamine oxidase inhibitors MAOIs with promethazine, you raise your risk of extrapyramidal symptoms. These symptoms include uncontrollable upward staring, eye and lid twitching, uncontrollable neck muscle contractions causing your head to twist or turn to one side and sticking out your tongue uncontrollably. Gene transfer and protein repair therapies are in the experimental, developmental stages. Talk to your doctor about for these and other new treatments being studied. Promethazine may also be used for other purposes not listed in this medication guide. What is the most important information I should know about rectal Promethegan promethazine rectal? Medical researchers are looking at gene transfer therapy. It involves introducing healthy genes into the lung cells of people who have cystic fibrosis. Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine hydrochloride should be carefully considered. For people with breathing problems: This drug may thicken the secretions in your breathing tubes. If you have asthma or chronic obstructive pulmonary disease COPD this may cause an asthma attack or make your COPD worse. The drug should not be taken during an acute asthma attack or if you have COPD. Promethazine is used for several reasons, including treating allergies, motion sickness, nausea and vomiting, anxiety before surgery, and pain after surgery. This medication may cause withdrawal reactions, especially if it has been used regularly for a long time more than a few weeks or in high doses. Promethazine may make your skin sensitive to sunlight. This infrequent side effect may occur even with usual prescribed doses. The lowest effective dose should be used, and other drugs that may slow down breathing should be avoided. For children under 12 years old, not use this product to treat or pain unless specifically directed by the doctor. Use of codeine is not recommended to treat and pain in children between 12 and 18 years old who have breathing problems. Interaction Checker. Enter a drug name and promethazine. It may slightly increase the risk of if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time. gefitinib nj

What should i avoid while taking promethazine

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking promethazine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. If patient complains of pain at the injection site during presumed IV injection, immediately discontinue injection and evaluate the possibility of intra-arterial placement of the needle or perivascular extravasation. The oral tablet is only available as a generic drug. Generic drugs usually cost less than brand-name versions. May ameliorate hemolytic disease of the newborn erythroblastosis fetalis when administered during pregnancy in Rh-sensitized women. Taking certain MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Avoid taking isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. April 25, 2016. Phenergan And Zyrtec Interactions Pentazine - strausser. Food and Drug Administration. Angioedema buildup of fluid deep in your skin or underneath your skin. May 4, 2017. Can take promethazine with Benadryl - Answers.

How to take promethazine

Do not use a household spoon because you may not get the correct dose. Not known whether promethazine is distributed into milk. 100 117 133 Discontinue nursing or the drug. Your doctor may suggest rinsing gently with saltwater but wait until the day after your surgery to do this. Precise mechanism of the CNS effects unknown. a b Antimotion sickness action apparently related to central anticholinergic effects. Using promethazine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. May 13, 2017. Promethazine Phenergan - Side Effects, Dosage. Camardo J. Dear health care professional letter regarding contraindications and warnings of Phenergan tablets and suppositories in pediatric patients. Some teens can drive themselves to and from the surgery. But if you have general anesthesia or pain drugs, your parents will need to drive. If you feel you have overdosed call poison control at 800 222-1222 or go to the emergency room right away. You can bring a parent or other caregiver with you to go over the procedure. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Your doctor may start you on a lower dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Promethazine with Codeine Oral Solution for a condition for which it was not prescribed. Do not give Promethazine with Codeine Oral Solution to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Promethazine with Codeine Oral Solution that is written for health professionals. This drug should not be used in children younger than 2 years. In children this age, this drug may cause slowed breathing that could be fatal. Caution should also be used when giving this drug to children older than 2 years. Other things, such as the amount of sample, the timing of the sample, the type of culture done, and recent use of antibiotics, can prevent the growth of bacteria or fungus in the culture. Quinn J, Calvert R. The disposition of promethazine in man. J Pharm Pharmacol. prometrium

Prescribing information for promethazine

Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; abnormal thoughts; agitation; change in the amount of urine produced; confusion; fainting; fast, slow, or irregular heartbeat; hallucinations; loss of coordination; mood or mental changes; muscle pain or stiffness; overexcitement; seizures; severe drowsiness; severe or persistent blurred vision, dizziness, headache, or lightheadedness; slow or irregular breathing; symptoms of infection eg, fever, chills; tremors; uncontrolled muscle movements eg, movements of the arms, legs, tongue, eyes; unusual bruising or bleeding; unusual sweating; vision problems; yellowing of the skin or eyes. Most people have little to no pain afterward. It may take a few days to feel back to normal, but you can go back to school, camp, or work the next day. May be administered rectally, by deep IM, or IV 117 133 in dosages identical to oral dosages. When used before surgery, promethazine may be used the night before or just before the procedure and may be continued afterwards as directed. January 29, 2017. Phenergan Promethazine Drug Information. Promethazine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. May 16, 2017. Can you take promethazine dm and zyrtec together? It is especially important when you take Promethazine with Codeine Oral Solution that you know exactly what dose to take. Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause. Codeine is changed into a strong drug in your body. In some people, this change happens faster and more completely than usual, which increases the risk of very seriousside effects. French. Temaril prescribing information. See Nervous System Effects under Cautions.

This can be painful

Take this medication by mouth as directed by your doctor, with or without food, usually every 4-6 hours as needed. Since dosing recommendations may vary, carefully follow your doctor's directions for taking this medication. Rubinstein A, Eidelman AI, Melamed J et al. Possible effect of maternal promethazine therapy on neonatal immunological functions. J Pediatr. Find patient medical information for Phenergan oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Take the drugs your doctor prescribes to ease your pain or swelling. It's not necessary to eat before taking promethazine. You should never take more promethazine than prescribed. Add salt to foods, especially during hot weather. Avoid analeptics which may cause convulsions. Narcotic analgesics may cause nausea and vomiting by stimulating the chemoreceptor trigger zone CTZ; however, they also depress the vomiting center, so that subsequent doses are unlikely to produce vomiting. Nausea is minimal after usual oral doses of codeine. Can you take promethazine with Claritin? What should I know regarding pregnancy, nursing and administering Promethazine-Codeine to children or the elderly? Global Group - Public WebSites. live casinos reviews livedealercasino. Six percent of ramelteon-treated patients in clinical trials discontinued due to an adverse event, compared to 2% in the placebo arms. The most frequent adverse events leading to discontinuation were somnolence, dizziness, nausea, fatigue, headache, and insomnia. The United States official Prescribing Information warns of rare cases of anaphylactic reactions, abnormal thinking, and suicide in patients with pre-existing depression. order sibutramine online shop usa

What conditions does promethazine treat

Inhibits the ability of fetal macrophages to bind Rh-positive erythrocytes. Avoid using other drugs that make you sleepy such as cold medicine, sleeping pills, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety. The activity of ramelteon at the MT 1 and MT 2 receptors is believed to contribute to its sleep-promoting properties, as these receptors, acted upon by endogenous melatonin, are thought to be involved in the maintenance of the circadian rhythm underlying the normal sleep-wake cycle. MAOI and phenothiazines are used concomitantly. Do not take Promethazine with Codeine Oral Solution if you are allergic to any of the ingredients in Promethazine with Codeine Oral Solution. See the end of this Medication Guide for a complete list of ingredients in Promethazine with Codeine Oral Solution. Advise patients that some people have a genetic variation that results in codeine changing into morphine more rapidly and completely than other people. Most people are unaware of whether they are an ultra-rapid codeine metabolizer or not. These higher-than-normal levels of morphine in the blood may lead to life-threatening or fatal respiratory depression or signs of overdose such as extreme sleepiness, confusion, or shallow breathing. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. Inhibits collagen-induced platelet aggregation in neonates whose mothers had received the drug during labor.

January 26, 2017 HostBlast

Limited experience with dialysis indicates that it is not helpful. This drug should not be given to a pregnant woman within 2 weeks of delivery because it raises her risk of bleeding. Researchers are also investigating protein repair therapy, or protein assist therapy. This treatment involves taking medicines that help the defective protein work more normally to allow a small amount of salt and water to move out of cells. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Possible sleep apnea and sudden infant death syndrome SIDS in infants and young children. 119 123 See Respiratory Effects under Cautions. Sucking may loosen blood clots that help your mouth heal. See Pediatric Use under Cautions. Signs and symptoms of overdosage with promethazine range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis and extensor-plantar reflexes Babinski reflex. If you miss a dose, take it as soon as you remember unless it's almost time for the next dose. Lie down on your left side and raise your right knee to your chest. A left-handed person should lie on the right side and raise the left knee. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. If you are prescribed this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Advise both patients and caregivers about the risks of respiratory depression and sedation if Promethazine with Codeine Oral Solution is used with benzodiazepines, alcohol, or other CNS depressants. You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you. When you take drugs called tricyclic antidepressants with promethazine, you may have drowsiness that is more extreme and lasts longer. atka.info spiriva

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Promethazine drug interactions

But coughing up large amounts of blood can be life-threatening. Therefore, this product is not recommended to treat in children younger than 6 years. Gusdon JP Jr, Herbst GA. The effect of promethazine hydrochloride on fetal and maternal lymphocytes. Am J Obstet Gynecol. Nutritional therapy to help replace lost nutrients. purchase crixivan nz crixivan

How should i take promethazine

Promethazine and Codeine. It is not known whether this drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Promethazine with Codeine Oral Solution should be given to a pregnant woman only if clearly needed. June 26, 2016. Phenergan Promethazine Drug Information: Description. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Consumer information about the medication CETIRIZINE - ORAL Zyrtec includes side effects, drug interactions, recommended dosages, and storage information.

This is known as TOLERANCE

This drug is not recommended to treat uncomplicated vomiting in children. It should only be used for extended periods of vomiting when the cause is known. Kahn A, Hasaerts D, Blum D. Phenothiazine-induced sleep apnea in normal infants. Pediatrics. May 23, 2016. Zyrtec Monograph for Professionals - Drugs.

Promethazine consumer information

Ramelteon also does not interfere with the activity of a number of selected enzymes in a standard panel. Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Prednisone. I am still itching at night and having. When prescribing codeine-containing drugs, healthcare providers should choose the lowest effective dose for the shortest period of time and inform patients and caregivers about these risks and the signs of morphine overdose.

Promethazine HCl Syrup promethazine hydrochloride syrup plain Plain in pediatric patients. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Codeine and its salts are well absorbed following both oral and parenteral administration. Some manufacturers state that promethazine also is contraindicated in patients with bone marrow depression, angle-closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction; 136 a b others state that the drug be used with caution in these patients.

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